JAY GROSSMAN, M.D.; MARY LOU CALLERAME, M.D.; JOHN J. CONDEMI, M.D., F.A.C.P.
The deposition of gamma globulins and complement at the dermal-epidermal (D-E) junction of normal-appearing skin was found by direct immunofluorescence in 54% of patients with systemic lupus erythematosus and in only one patient with procainamide-induced lupus. No patients with rheumatoid arthritis or other antinuclear-antibody-positive connective tissue diseases showed this deposition. The D-E junction staining was found only in patients with clinically active systemic lupus erythematosus, but it could not be correlated with specific organ system involvement.
GROSSMAN J, CALLERAME ML, CONDEMI JJ. Skin Immunofluorescence Studies on Lupus Erythematosus and Other Antinuclear-Antibody-Positive Diseases. Ann Intern Med. ;80:496–500. doi: 10.7326/0003-4819-80-4-496
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Published: Ann Intern Med. 1974;80(4):496-500.
Lupus Erythematosus, Rheumatology.
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