D. ROBERT WEBB, M.D.; JOHN J. CONDEMI, M.D., F.A.C.P.
A 43-year-old woman with far-advanced chronic obstructive lung disease had selective IgA deficiency. Twenty-eight members of her large family were studied; IgA deficiency was found in 6, and 7 others had borderline levels. Serum immunoglobulins G, M, and E were normal, as were alpha-1 antitrypsin levels. Clinical emphysema was found in the proband's mother and two brothers. Intermediate inheritance of IgA deficiency in this family is suggested by a history of consanguinity and intermediate levels of IgA in numerous family members; however, several obligate heterozygous individuals have normal levels. A relation between immunoglobulin deficiency and chronic obstructive lung disease would fit the hypothesis of a proteolytic cause for this disease.
D. ROBERT WEBB, JOHN J. CONDEMI. Selective Immunoglobulin A Deficiency and Chronic Obstructive Lung Disease: A Family Study. Ann Intern Med. 1974;80:618–621. doi: 10.7326/0003-4819-80-5-618
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Published: Ann Intern Med. 1974;80(5):618-621.
Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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