ARMAND LITTMAN, M.D.
This issue welcomes oral bethanechol (Urecholine®1) as a potentially useful treatment for patients with heartburn who have not been helped with conventional measures. At the Naval Hospital in Philadelphia, Farrell, Roling, and Castell (1) have convincingly shown that patients with this therapeutically difficult condition get significant relief that is apparently not otherwise obtainable. Which patients should be treated with bethanechol? Will bethanechol
work in your patients and mine? Some aspects of the design of this study weaken one's confidence in the conclusions and some aspects strengthen it. As with most literature on therapy of gastrointestinal disease—caveat emptor.
The population studied
LITTMAN A. Heartburn and Bethanechol. Ann Intern Med. ;80:664–665. doi: 10.7326/0003-4819-80-5-664
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Published: Ann Intern Med. 1974;80(5):664-665.
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