HAROLD L. ISRAEL, M.D., F.A.C.P.
To the editor: Having been an early advocate (1) of isoniazid prophylaxis, I feel an obligation to urge termination of this practice. In 1960 isoniazid seemed to be an innocuous and inexpensive drug, and tuberculosis was still a major problem. Now, because of outbreaks of hepatitis in many parts of the country, it is clear that close and costly surveillance of isoniazid users is mandatory, and even this may not avert severe or chronic hepatic damage. Dr. Murphy (2) has raised the proper issue by asking whether tuberculosis today causes "enough morbidity and mortality to justify the use of prophylactic
ISRAEL HL. Stop Isoniazid Prophylaxis. Ann Intern Med. ;80:672–673. doi: 10.7326/0003-4819-80-5-672_2
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Published: Ann Intern Med. 1974;80(5):672-673.
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