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The recent profusion of immunogenetic studies makes this monograph on heritable regulation of antibody variability a welcome addition to the literature. In this concisely written, readable work, Dr. Smith summarizes the bulk of amino-acid sequence studies done during the past decade and the relations of light- and heavy-chain descent that have been derived. The discussion of CL and CH region evolution and of immunoglobulin class and subclass development is succinct and engaging. Current somatic and germ-line mutation theories of antibody diversity are systematically surveyed and evaluated. The author's own preference for germ-line mechanisms is convincingly defended. The problem of allotypic
The Variation and Adaptive Expression of Antibodies.. Ann Intern Med. ;80:679–680. doi: 10.7326/0003-4819-80-5-679_2
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Published: Ann Intern Med. 1974;80(5):679-680.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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