RAMESH C. GUPTA, M.D.; JAMES C. STEIGERWALD, M.D.
To aid in the early diagnosis of pyogenic arthritis, the nitroblue tetrazolium test was done on the blood and synovial fluid of patients with culture-proved bacterial arthritis. Increased numbers of nitroblue tetrazolium positive cells were found in the synovial fluid of seven of the eight patients with bacterial joint infections. The nitroblue tetrazolium test done simultaneously in the peripheral blood was less helpful, with only four of seven patients showing positive results. In the control groups of rheumatoid arthritis, crystal-induced arthritis, and Reiter's syndrome and psoriasis, all values were within the normal range. These findings show that the histochemical nitroblue tetrazolium test in synovial fluid is a simple and useful method for the early detection of pyogenic arthritis.
GUPTA RC, STEIGERWALD JC. Nitroblue Tetrazolium Test in the Diagnosis of Pyogenic Arthritis. Ann Intern Med. ;80:723–726. doi: 10.7326/0003-4819-80-6-723
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Published: Ann Intern Med. 1974;80(6):723-726.
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