WALTER M. BORTZ, M.D.
Elevation of serum cholesterol level is caused by decreased output and increased input. Increased input, as manifested by increased synthesis, seems to be the more common mechanism. Many of the acknowledged risk factors in the development of coronary artery disease are characterized by increased cholesterol formation. It is proposed that the most frequent biologic risk factor that underlies a large number of the many other seemingly separate effectors is the excessive flux of fat to the liver.
BORTZ WM. The Pathogenesis of Hypercholesterolemia. Ann Intern Med. ;80:738–746. doi: 10.7326/0003-4819-80-6-738
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Published: Ann Intern Med. 1974;80(6):738-746.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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