JOSEPH WYBRAN, M.D.; HUGH FUDENBERG, M.D.
In the past few years medical literature has blossomed with papers on the detection of B and T lymphocytes and their quantitation. Experiments in animals have clearly shown that the immune system can be divided into two components: humoral and cellular. The antibodies mediating humoral immunity are synthesized in B lymphocytes and plasma cells, whereas cellular immunity is mediated mainly through T lymphocytes. In birds, the lymphocytes' acquisition of B cell characteristics depends on the bursa of Fabricus, a juxtacloacal organ. The equivalent of the bursa in mammals is ill defined, but in our laboratory it is believed to be
WYBRAN J, FUDENBERG H. How Clinically Useful is T and B Cell Quantitation?. Ann Intern Med. ;80:765–767. doi: 10.7326/0003-4819-80-6-765
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Published: Ann Intern Med. 1974;80(6):765-767.
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