JOSEPH I. MATTHEWS; DAVID STAGE
To the editor: Aspirin and indomethacin are nonsteroidal, chemically dissimilar compounds that share several common properties. Both are anti-inflammatory, analgesic, and antipruritic agents of therapeutic value in several rheumatic diseases. Both may cause similar side effects because of gastrointestinal or central nervous system toxicity. The ingestion of aspirin may result in the exacerbation of preexisting asthma in susceptible patients (1, 2). Some cross-reactivity apparently exists, in that indomethacin may also induce asthma in patients with similar sensitivity to aspirin. Aspirin commonly (3) and indomethacin rarely (4) have been associated with the development of urticarial reactions. To our knowledge, however, there
MATTHEWS JI, STAGE D. Indomethacin, Aspirin, and Urticaria. Ann Intern Med. ;80:771. doi: 10.7326/0003-4819-80-6-771_1
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Published: Ann Intern Med. 1974;80(6):771.
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