KENNETH J. PRESCOTT, M.D.
To the editor: Dr. Edward Genton stated in his review, "Guidelines for Heparin Therapy," (Ann Intern Med 80:77-82, 1974) that the amount of heparin anticipated for a 12- to 24-hour period is diluted in from 500 to 1000 ml 5% glucose or saline solution. Jacobs and associates (1) have shown that there is a rapid inactivation of heparin in solutions containing dextrose or lactate.
Since saline seems to be the only solution in which heparin is stable, its use as a constant drip would be limited in patients requiring sodium restriction.
PRESCOTT KJ. Heparin Therapy. Ann Intern Med. ;80:773–774. doi: 10.7326/0003-4819-80-6-773_2
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Published: Ann Intern Med. 1974;80(6):773-774.
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