RICHARD B. DAVIS, M.D., F.A.C.P.
To the editor: The recently published paper by Smith, Dodds, and Tartaglia (Ann Intern Med 79:828-834, 1973) presents an excellent discussion of the vagaries of laboratory testing and the clinical meaning of platelet functional abnormalities. Platelet functional defects present a spectrum of abnormalities, and the ultrastructural aspects of platelet morphology may manifest a similar spectrum of differences. Although the "Swiss-cheese" platelet may be nearly unique in humans, it has clearly been characterized in our laboratory as one of the responses to injury caused by lead acetate (1). In approximately one fourth of all platelets observed after lead injection, specific vacuolar
DAVIS RB. "Swiss-Cheese" Platelets. Ann Intern Med. ;80:776. doi: 10.7326/0003-4819-80-6-776_1
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Published: Ann Intern Med. 1974;80(6):776.
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