GEORGE C. LIANG, M.D.; PETER A. SIMKIN, M.D.; MART MANNIK, M.D.
Immunofluorescent studies were done on 15 consecutive temporal artery biopsy specimens and on control specimens obtained from 10 patients after they died from unrelated diseases. Four different patterns of immunoglobulin deposition were seen. "Cytoplasmic" and "elastic" patterns occurred together only in three patients with histologic giant cell arteritis; these patterns were not seen in control specimens. "Nuclear" deposition was seen in three patients who had circulating antinuclear antibodies. The "linear" pattern was nonspecific, because it was found in both patient and control specimens. These findings parallel those of other forms of vasculitis, which suggests that antibodies participate in the pathogenesis of giant cell arteritis. The immunoglobulins in these vessels may be antibodies to a component of the arterial wall (presumably elastin), or they may result from deposition of circulating immune complexes.
GEORGE C. LIANG, PETER A. SIMKIN, MART MANNIK. Immunoglobulins in Temporal Arteries: An Immunofluorescent Study. Ann Intern Med. 1974;81:19–24. doi: 10.7326/0003-4819-81-1-19
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Published: Ann Intern Med. 1974;81(1):19-24.
Giant Cell Arteritis/Polymyalgia Rheumatica, Neurology, Rheumatology, Vasculitides.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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