S. R. WEISS, M.D.
To the editor: The glucagon stimulation test was initially described by Lawrence and Forland (1) as an adjunct to the diagnosis of pheochromocytoma, to avoid the side effects commonly encountered with the use of histamine. The tyramine provocative test (2) is generally a reliable, safer way to provoke hypertension in subjects suspected of harboring a chromaffin tumor. Although the tyramine test is valuable in diagnosing sporadic pheochromocytomas, it can be misleading if the pheochromocytoma is associated with other endocrine tumors, particularly medullary thyroid carcinoma (3). Because of common lack of response to tyramine under such conditions, a glucagon provocation should
WEISS SR. Testing in Pheochromocytoma and Another Endocrine Tumor. Ann Intern Med. 1974;81:116–117. doi: 10.7326/0003-4819-81-1-116_2
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Published: Ann Intern Med. 1974;81(1):116-117.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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