B. WlNFRED RUFFNER, M.D.
To the editor: The development of acute myelomoncytic leukemia after treatment with alkylating agents is being reported with increasing frequency. This letter concerns a patient in whom concomitant treatment with androgens may have influenced the course of her disease. Four other reports of androgen and alkylating agent therapy preceding acute leukemia are also cited.
In 1963 the patient underwent radical mastectomy for infiltrating ductal carcinoma, with metastasis to axillary nodes. She was 30 years old at that time. After surgery she received prophylactic radiotherapy to the chest wall and axillary, internal mammary, and supraclavicular areas.
In 1965 pulmonary metastases were
RUFFNER BW. Androgen Role in Erythroleukemia After Treatment with Alkylating Agents. Ann Intern Med. ;81:118–119. doi: 10.7326/0003-4819-81-1-118
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Published: Ann Intern Med. 1974;81(1):118-119.
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