LESLIE S. LIBOW, M.D., F.A.C.P.; FRANK ROSS, M.D.; KENNETH GOLDBERG, M.D.
To the editor: We recently encountered two cases of elderly patients with hypercalcemia secondary to "one tablet per day" of vitamin D administration. The vitamin D (calciferol) was given for osteoporosis of the lumbar spine accompanied by pain and vertebral collapse. In one case, 50 000 units (one tablet) per day of vitamin D was given with daily administration of calcium gluconate, 600 mg, fluoxymesterone (Halotestin®*) and chlorothiazide, for a total of 4½ months. In the other, 50 000 units per day of vitamin D was given for 1 year, without supplemental calcium or any other medication. Both patients were
LIBOW LS, ROSS F, GOLDBERG K. "One Tablet Per Day" for Osteoporosis: Hypercalcemia. Ann Intern Med. ;81:120–121. doi: 10.7326/0003-4819-81-1-120_2
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Published: Ann Intern Med. 1974;81(1):120-121.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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