JOHN C. KLOCK, M.D.
To the editor: Ethchlorvinol (Placidyl®, Abbott Laboratories, North Chicago, Illinois) has been known to cause serious central nervous system depression and cardiovascular collapse if taken in large amounts (1-4). Its spectrum of hematologic toxicity is not known aside from a case of immune thrombocytopenia (5).
A previously healthy 29-year-old physician ingested between 200 and 250 500-mg Placidyl capsules in a suicide attempt (13 July 1973). He was hospitalized within 40 minutes of ingestion. Examination showed a lethargic man (75 kg) with a blood pressure of 100/80 mm Hg; pulse, 50/min; respiration, 10/min; and temperature, 35.6 °C. Gastric lavage produced many
KLOCK JC. Hemolysis and Pancytopenia in Ethchlorvynol Overdose. Ann Intern Med. ;81:131–132. doi: 10.7326/0003-4819-81-1-131_2
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Published: Ann Intern Med. 1974;81(1):131-132.
Emergency Medicine, Hematology/Oncology.
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