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The explanation of one of the basic concepts of immunology, how the immune system distinguishes "self" from "nonself," is unfolding slowly, accompanied by vigorous argument. Several aspects of this problem are discussed in the four essays of this small book. This topic is of more than academic interest to the clinician since it underlies many clinical problems, including allograft tolerance, tumor rejection, and autoimmune disease.
Leslie's and Cohen's essay on the active sites of immunoglobulin molecules and G. J. V. Nossal's review of the laboratory evidence for the possible mechanisms of immune tolerance constitute the more substantive half of the
Essays in Fundamental Immunology: 1.. Ann Intern Med. ;81:135–136. doi: 10.7326/0003-4819-81-1-135_3
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Published: Ann Intern Med. 1974;81(1):135-136.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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