ROBERT J. JACOBSON, M.B., B.Ch., F.R.C.P.(C); DUDLEY P. JACKSON, M.D., F.A.C.P.
The morphologic features of microangiopathic hemolytic anemia were assessed retrospectively in the peripheral blood of 40 patients with defibrination syndromes associated with various clinical conditions. All patients had hypofibrinogenemia, and all but six had thrombocytopenia. Seventeen of the 40 patients had fragmented erythrocytes in their peripheral blood in association with the episode of defibrination. The presence or absence of erythrocyte fragmentation did not correlate with the degree of hypofibrinogenemia or thrombocytopenia, nor with the duration of the coagulopathy. The microangiopathic changes in the peripheral blood, especially the more severe changes, were associated with fibrin occlusion to small blood vessels and significant organ damage.
JACOBSON RJ, JACKSON DP. Erythrocyte Fragmentation in Defibrination Syndromes. Ann Intern Med. ;81:207–209. doi: 10.7326/0003-4819-81-2-207
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Published: Ann Intern Med. 1974;81(2):207-209.
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