A. MEISTER, M.D.
The γ-glutamyl cycle consists of six enzyme-catalyzed reactions that account for the synthesis and degradation of glutathione, a tripeptide that is found in virtually all living cells. It has been proposed that the γ-glutamyl cycle functions in the transport of amino acids across cell membranes. The status of research on the γ-glutamyl cycle is considered. There is evidence that the cycle functions in the kidney and in other tissues. Patients with diseases associated with a deficiency of a specific enzyme of the γ-glutamyl cycle have been found, and the nature of the biochemical defects has been explored.
MEISTER A. Theγ-Glutamyl Cycle: Diseases Associated with Specific Enzyme Deficiencies. Ann Intern Med. ;81:247–253. doi: 10.7326/0003-4819-81-2-247
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Published: Ann Intern Med. 1974;81(2):247-253.
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