ALEXANDER S. WIENER, M.D., F.A.C.P., F.R.C.P.
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To the editor: This letter presents a new theory of adaptive antibody formation and a hypothesis to account for "crib deaths" in infants 2 to 5 months of age.
It is postulated that suitably processed antigen acts as a template for antibody formation but that instead of the antibody molecules being built up from individual amino acids, these molecules are formed from genetically determined polypeptide chains (that make up the constant or C portion of the antibody molecule), which are joined together by protein synthetases at appropriate angles with selected amino acids or oligopeptides that make up the variable or
ALEXANDER S. WIENER. Theory of Adaptive Antibody Formation and "Crib Death". Ann Intern Med. 1974;81:266. doi: 10.7326/0003-4819-81-2-266_1
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Published: Ann Intern Med. 1974;81(2):266.
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