ANGELA M. HILTON, M.B., CH.B., M.R.C.P. (U.K); I. W. DYMOCK, M.B., M.R.C.P. ED., F.R.C.P. (GLASG)
To the editor: The reports of aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus (Ann Intern Med 80:1-8 and 80:74-76, 1974) show a clear relation between abnormal liver function and salicylate dosage. In three of the four patients described, liver biopsies were done when elevation of aminotransferases occurred. The biopsy specimens showed varied abnormalities, including one example of chronic active hepatitis. But in none of these cases was a repeat liver biopsy done when the biochemical changes had resolved after aspirin dosage was reduced.
A recent study from this department of 30 patients with liver disease and joint symptoms1 included
HILTON AM, DYMOCK IW. Aspirin Hepatotoxicity. Ann Intern Med. ;81:271–272. doi: 10.7326/0003-4819-81-2-271
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Published: Ann Intern Med. 1974;81(2):271-272.
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