MARTIN H. STEINBERG, M.D., F.A.C.P.
To the editor: Rosner and Karayalcin (1) have confirmed the work of Wajima and Kraus (2), who first noted low leukocyte alkaline phosphatase activity in the granulocytes of individuals with sickle-cell anemia. They believed this finding was unusual in that the opposite would be expected; an elevated leukocyte alkaline phosphatase level because of the chronic stressful state of persons with sickle-cell disease (1).
The cellular content of leukocyte alkaline phosphatase depends partly on the degree of maturity of the granulocyte. This enzyme first becomes evident during the myelocyte stage of development, when the specific neutrophilic granules appear, and its quantity
STEINBERG MH. Leukocyte Alkaline Phosphatase. Ann Intern Med. ;81:274. doi: 10.7326/0003-4819-81-2-274_2
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Published: Ann Intern Med. 1974;81(2):274.
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