SARAH S. DONALDSON, M.D.; JANE M. GLICK, PH.D.; JORDAN R. WILBUR, M.D.
To the editor: Adriamycin has antineoplastic activity in malignant lymphomas, bone and soft tissue sarcomas, neuroblastomas, and some carcinomas (1). Toxicity reported includes leukopenia, stomatitis, mucositis, nausea, vomiting, alopecia, and cardiomyopathy (1). There are no reports of a "recall phenomenon," reactivation of latent radiation effects in a previously irradiated field, with adriamycin, similar to those recognized with actinomycin D.
We have now seen two children who have had such a "recall phenomenon" associated with the administration of adriamycin. With increasing use of adriamycin combined with irradiation in solid tumor therapy, we believe our observations may be important to others.
DONALDSON SS, GLICK JM, WILBUR JR. Adriamycin Activating a Recall Phenomenon After Radiation Therapy. Ann Intern Med. ;81:407–408. doi: 10.7326/0003-4819-81-3-407
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Published: Ann Intern Med. 1974;81(3):407-408.
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