ROBERT S. BENJAMIN, M.D.; PETER H. WIERNIK, M.D.; NICHOLAS R. BACHUR, M.D., PH.D.
To the editor: We read with interest the recent review of Blum and Carter on adriamycin (1). We are concerned, however, lest the authors' apparent misinterpretation of our data confuse your readers, and therefore, we should like to clarify certain issues, as well as to update the references to our work.
With regard first to biochemistry, in 1972 we were unable to demonstrate the presence of a reductase for adriamycin, but we have subsequently identified such a reaction and have isolated adriamycinol as a major metabolite of adriamycin in human urine (2, 3), bile (4), and plasma (3).
BENJAMIN RS, WIERNIK PH, BACHUR NR. Adriamycin. Ann Intern Med. ;81:414–415. doi: 10.7326/0003-4819-81-3-414
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Published: Ann Intern Med. 1974;81(3):414-415.
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