WILLIAM A. PARKER, PHARM. D.
To the editor: Primidone-induced hematologic reactions are generally quite rare. As discussed by Booker (1), primidone has been implicated in producing folic acid deficiency and megaloblastic anemia after continual administration. Hemorrhagic disease of newborns and leukopenia have also been reported (1), but rarely, and Rozbicka (2) has reported one patient with thrombocytopenic purpura. In general, authors reporting on large series of patients have commented on the relative immunity of the bone marrow to adverse effects of primidone. The following case report describes a primidone-induced thrombocytopenia.
The patient was a 26-year-old white woman with major motor seizures and a history of
PARKER WA. Primidone Thrombocytopenia. Ann Intern Med. ;81:559–560. doi: 10.7326/0003-4819-81-4-559
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Published: Ann Intern Med. 1974;81(4):559-560.
Hematology/Oncology, Platelet Disorders.
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