MICHAEL N. HARTNETT, M.D.; WILL LANE, M.D.; WILLIAM M. BENNETT, M.D.
To the editor: Nonoliguric failure is a well-documented complication of anesthesia with the fluorinated hydrocarbon methoxyflurane (1, 2). This nephrotoxicity is related to the dose of inorganic fluoride (2). Although the metabolism of enflurane (Ethrane®1), yields less inorganic fluoride, enflurane has caused renal dysfunction in animals (3). A recent report implicated enflurane in deterioration of renal function in a transplant patient undergoing surgery (4). The following case report may represent a second occurrence and is being communicated to alert internists to potential nephrotoxicity of this anesthetic.
A 42-year-old woman was admitted for elective ankle fusion. Known medical problems included chronic
HARTNETT MN, LANE W, BENNETT WM. Nonoliguric Renal Failure and Enflurane. Ann Intern Med. ;81:560. doi: 10.7326/0003-4819-81-4-560
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Published: Ann Intern Med. 1974;81(4):560.
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