BRIAN S. ANDREWS, M.D.; SOLOMON POSEN, M.D.; STEPHEN PODOLSKY, M.D., F.A.C.P.
To the editor: Various endocrinopathies have been described in association with polyostotic fibrous dysplasia (Albright's syndrome). These include precocious puberty in females, hyperthyroidism, acromegaly, Cushing's syndrome, and hyperparathyroidism (1-4). The nature of these associations is obscure. Suggested mechanisms include the abnormal secretion of pituitary trophic hormones or hypothalamic releasing factors because of the sclerotic lesions at the base of the skull or because of a congenital hypothalamic abnormality (5). We recently had the opportunity to study two patients with polyostotic fibrous dysplasia and hyperthyroidism. Neither showed elevation of immunoassayable thyrotrophin.
A 26-year-old man had 18 spontaneous fractures since
ANDREWS BS, POSEN S, PODOLSKY S. Thyrotrophin in Albright's Syndrome with Hyperthyroidism. Ann Intern Med. ;81:561. doi: 10.7326/0003-4819-81-4-561
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Published: Ann Intern Med. 1974;81(4):561.
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