STEVEN B. LEICHTER, M.D.; WILLIAM H. DAUGHADAY, M.D.
A 48-year-old woman with mild hirsutism had extremely elevated urinary excretion of 17-ketosteroids (as high as 1555 mg per day). At operation, a large, benign adenoma was found. The case was unusual in that she had severe hypocholesterolemia that was first documented 2 years before surgery. Postoperatively, plasma cholesterol levels promptly returned to normal. It is proposed that the markedly elevated production of steroid substances by this tumor led to a massive diversion of plasma cholesterol, exceeding any compensatory increase in hepatic cholesterol synthesis. This consequence of steroid overproduction has hitherto been unrecognized.
LEICHTER SB, DAUGHADAY WH. Massive Steroid Excretion and Hypocholesterolemia with an Adrenal Adenoma: Report of a Case. Ann Intern Med. ;81:638–640. doi: 10.7326/0003-4819-81-5-638
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Published: Ann Intern Med. 1974;81(5):638-640.
Adrenal Disorders, Cardiology, Coronary Risk Factors, Dyslipidemia, Endocrine and Metabolism.
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