RICHARD S. STEIN, M.D.
To the editor: Combinations of factor VIII concentrates and alkylating agents have met with variable success in the treatment of hemophiliacs having inhibitors of factor VIII. In some cases the anamnestic response was blocked (1, 2), and in one patient with a low titer of inhibitor, the inhibitor disappeared and repeat administration of factor VIII in the absence of further immunosuppression did not provoke the reappearance of the antibody (1). In similar but not identical circumstances, the characteristic anamnestic response to treatment has been observed (3). We report here an additional case in which an anamnestic response was blocked by
STEIN RS. Hemophilia: Cyclophosphamide and Factor VIII Concentrate. Ann Intern Med. ;81:706–707. doi: 10.7326/0003-4819-81-5-706_2
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Published: Ann Intern Med. 1974;81(5):706-707.
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