JOHN C. MARSH, M.D.
To the editor: In 1972 McPhedran and co-workers (1) reported a patient from this institution with renal carcinoma and the triad of fever, anemia, and hyperhaptoglobinemia (2). An elevation in alpha-2 globulin, marrow plasmocytosis, thrombocytosis, leukocytosis, hyperfibrinogenemia, and hypoferremia were also observed, which became normal after a left nephrectomy in August 1969 with the removal of a 6 cm clear cell adenocarcinoma. I wish to report follow-up information; this patient has developed metastases over the next 5 years in different sites with similar chemical and hematologic changes (Table 1).
After surgery this patient was well until June 1972, when a
MARSH JC. Renal Carcinoma: Fever, Anemia, and Hyperhaptoglobinemia. Ann Intern Med. 1974;81:707–708. doi: 10.7326/0003-4819-81-5-707
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Published: Ann Intern Med. 1974;81(5):707-708.
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