IVAN P. LAW, M.D., MAJ MC
To the editor: Recent reports of cerebral parenchymatous degeneration as a complication in children with central nervous system (CNS) leukemia and primary brain tumors who were treated with intrathecal methotrexate and cranial irradiation (1, 2) have prompted us to report this occurrence in an adult with acute lymphoblastic leukemia.
This 21-year-old, white man with acute lymphoblastic leukemia was in remission for a year and then was found to have bone marrow relapse and meningeal involvement. A complete CNS remission was obtained with intrathecal methotrexate (12 mg/m2) and cranial irradiation with the midline dose of 2000 rads in 17 days. Six
LAW IP. Adult Acute Leukemia: Cerebral Degeneration. Ann Intern Med. ;81:709. doi: 10.7326/0003-4819-81-5-709_1
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Published: Ann Intern Med. 1974;81(5):709.
Hematology/Oncology, Leukemia/Lymphoma, Neurology.
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