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This subject is placed in its correct perspective by recalling that, although the major physiological actions of the gastrointestinal hormones have been known for 70 years, the amino acid sequence of gastrin was described in 1964 and that of secretin in 1970. After a slow start, progress during the past decade has been rapid. The structures of other gastrointestinal hormones, cholecystokinin-pancreozymin (CCK-PZ), gastric inhibitory peptide (GIP), vasoactive intestinal peptide (VIP), motilin, and enteroglucagon, have been elucidated. Sensitive radioimmunoassays have been or are being developed for their measurement. Multiple primary and secondary actions of these hormones on smooth muscle contractility, sphincteric
Endocrinology of the Gut.. Ann Intern Med. ;81:723–724. doi: 10.7326/0003-4819-81-5-723_3
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Published: Ann Intern Med. 1974;81(5):723-724.
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