ROBERT C. GOLDSTEIN, M.D.; ARTHUR D. SCHWABE, M.D., F.A.C.P.
Chronic colchicine therapy has been advocated for suppression of the painful, febrile paroxysms of familial Mediterranean fever. To evaluate the effect of this treatment, a controlled, double-blind study with colchicine and placebo was conducted on 10 selected patients for a 6-month period. Either colchicine, 0.6 mg, or placebo was given orally at a dosage of one tablet three times a day for 3 months; then the other agent was administered for an additional 3 months. Fifty-nine attacks occurred in nine patients during the placebo trial, but there were only five in two patients during colchicine therapy. The results are statistically significant (P < 0.002) and suggest that chronic colchicine administration may be effective in preventing attacks in this disorder.
GOLDSTEIN RC, SCHWABE AD. Prophylactic Colchicine Therapy in Familial Mediterranean Fever: A Controlled, Double-Blind Study. Ann Intern Med. ;81:792–794. doi: 10.7326/0003-4819-81-6-792
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Published: Ann Intern Med. 1974;81(6):792-794.
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