OSCAR D. RATNOFF, M.D.
The successful use of concentrates of human plasma rich in antihemophilic factor (factor VIII) in the treatment of classic hemophilia and von Willebrand's disease has encouraged the hope that analagous preparations of the vitamin K-dependent clotting factors might be helpful in the care of the much larger group of patients with deficiencies of one or more of the components of the so-called prothrombin complex. A striking property shared by the four recognized vitamin K-dependent clotting factors—Christmas factor (factor IX), factor VII, Stuart factor (factor X), and prothrombin (factor II)—is their adsorption onto certain insoluble salts, for example, barium sulfate or
OSCAR D. RATNOFF. Prothrombin Complex Preparations: A Cautionary Note. Ann Intern Med. 1974;81:852–853. doi: 10.7326/0003-4819-81-6-852
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Published: Ann Intern Med. 1974;81(6):852-853.
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