G. D. MOLNAR, M.D., PH.D., F.A.C.P.; F. J. SERVICE, M.D., PH.D., F.A.C.P.
Three recent papers in the British Medical Journal (1-3) report that continuous infusion of insulin at low dosage is an effective, safe, and simple treatment of severe hyperglycemia. Most of the 62 patients (in the three series) were ketoacidotic and comatose. These patients were continuously infused with unmodified (regular) insulin in saline at average rates of 4 to 8 units per hour. The therapy was impressively effective: in one of the studies (3), a mean (± SE) total of 39.2 ± 6.6 units satisfactorily regulated the diabetes in 6.4 ± 0.9 hours. In another study (1), the ratio of β
MOLNAR GD, SERVICE FJ. Low-Dosage Continuous Insulin Infusion for Diabetic Coma. Ann Intern Med. ;81:853–854. doi: 10.7326/0003-4819-81-6-853
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Published: Ann Intern Med. 1974;81(6):853-854.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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