JORGE E. MALDONADO, M.D., PH.D., F.A.C.P.
To the editor: Two reports (1, 2) have recently appeared in the Annals of Internal Medicine concerning platelets with a widely dilated open canalicular system and the ultrastructural appearance described by the term "Swiss-cheese" platelets. In the first paper (1), a patient with a mild bleeding tendency had giant and vacuolated platelets. Initially this patient had laboratory features of thrombasthenia, with later changes more consistent with thrombopathia. More recently, Davis (2) reported that Swiss-cheese platelets could be induced experimentally in rats by injection of lead acetate, and he illustrated similarly vacuolated platelets from a case of familial thrombocytopenia.
MALDONADO JE. "Swiss-Cheese" Platelets. Ann Intern Med. ;81:860–861. doi: 10.7326/0003-4819-81-6-860_2
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Published: Ann Intern Med. 1974;81(6):860-861.
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