K. J. RAO, M.D.; MYRON MILLER, M.D.; ARNOLD MOSES, M.D.
The occurrence of water intoxication in patients who have the ability to dilute urine normally is very unusual (1). Normal adults can excrete between 10 and 14 ml/min of solute-free water, and it is an unusual circumstance which results in the ingestion of sufficiently more water than this so that significant dilutional hyponatremia develops. We wish to report two cases of patients we have recently observed, both of whom had a psychiatric background and who were being treated with thioridazine (Mellaril®) at the time of the water intoxication.
The first patient was a 51-year-old man admitted to the hospital because
RAO KJ, MILLER M, MOSES A. Water Intoxication and Thioridazine (Mellaril®). Ann Intern Med. ;82:61. doi: 10.7326/0003-4819-82-1-61_1
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Published: Ann Intern Med. 1975;82(1):61.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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