LAWRENCE N. PARKER, M.D.
Drugs of the thioamide type, introduced during the 1940s for the treatment of thyrotoxicosis, were occasionally noted to produce jaundice. This effect was noted mostly with thiouracil, methylthiouracil, and thiobarbital (1). Due to this and other toxicities, antithyroid therapy with two newer thioamides, propylthiouracil and methimazole, has replaced the earlier drugs. However, a case of severe hepatitis and jaundice temporally associated with propylthiouracil administration, and regressing with cessation of propylthiouracil therapy has recently been encountered by the author.
A 9-year-old girl was diagnosed as having Graves' disease evidenced by markedly thyrotoxic signs and symptoms, a diffuse goiter, an 131I uptake
PARKER LN. Hepatitis and Propylthiouracil. Ann Intern Med. ;82:228–229. doi: 10.7326/0003-4819-82-2-228_2
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Published: Ann Intern Med. 1975;82(2):228-229.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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