SAUL W. ROSEN, PH.D., M.D., F.A.C.P.; BRUCE D. WEINTRAUB, M.D.
Polyendocrine syndromes have been described for more than two decades. They include syndromes of endocrine deficiency as well as endocrine excess. Primary insufficiency of thyroid and adrenal cortex (the Schmidt syndrome) may be associated with additional endocrine deficits, notably diabetes mellitus or ovarian failure (1). The syndromes of polyendocrine excess fall into three main categories. In multiple endocrine adenomatosis (MEA) type I (the Wermer syndrome) hyperplasia, adenoma, or carcinoma of one or more endocrine glands is inherited as an autosomal dominant. The parathyroids, pancreatic islets, and pituitary are most commonly affected. These patients are known to have an increased incidence
ROSEN SW, WEINTRAUB BD. Humours, Tumors, and Caveats. Ann Intern Med. ;82:274–276. doi: 10.7326/0003-4819-82-2-274
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Published: Ann Intern Med. 1975;82(2):274-276.
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