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Although the role of the "law of the heart" in the normal regulation of cardiac function has been much debated since it was propounded sixty years ago, its underlying mechanism has seemed quite clear. Variations in the end-diastolic volume of the ventricle change the degree of overlap of the thick and thin filaments within the sarcomeres and alter the number of crossbridges formed following activation. During the last decade, several investigations have indicated that other factors are involved. Several leading cardiac physiologists met in London in September 1973 to discuss these new developments. This book contains 13 papers presented at
The Physiological Basis of Starling's Law of the Heart.. Ann Intern Med. 1975;82:294–295. doi: 10.7326/0003-4819-82-2-294_2
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Published: Ann Intern Med. 1975;82(2):294-295.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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