ROBERT N. ALSEVER, M.D.; J. PETER ROBERTS, M.D.; JOHN G. GERBER, M.D.; MARY E. MAKO, M.S.; ARTHUR H. RUBENSTEIN, M.D., F.A.C.P.
Hypoglycemia coexisting with very low plasma immunoreactive insulin concentrations was found in a 78-year-old woman with an insulinoma. However, the absolute proinsulin levels during hypoglycemia were elevated (0.9 to 1.4 ng/ml), accounting for 66.5% of the total circulating immunoreactive insulinlike material. The raised serum proinsulin concentrations together with an abnormal proinsulim:insulin ratio proved to be of critical importance in establishing the diagnosis of an islet-cell tumor in this patient.
ALSEVER RN, ROBERTS JP, GERBER JG, MAKO ME, RUBENSTEIN AH. Insulinoma with Low Circulating Insulin Levels: The Diagnostic Value of Proinsulin Measurements. Ann Intern Med. ;82:347–350. doi: 10.7326/0003-4819-82-3-347
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Published: Ann Intern Med. 1975;82(3):347-350.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Gastroenterology/Hepatology.
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