PETER R. MAROKO, M.D.; DENNIS M. DAVIDSON; PETER LIBBY, M.D.; ARTHUR D. HAGAN; EUGENE BRAUNWALD, M.D., F.A.C.P.
The effect of hyaluronidase on myocardial ischemic injury was examined in 13 patients with acute myocardial infarction, and the results were compared with 11 patients who did not receive hyaluronidase. A 35-electrode precordial mapping method was used to assess the rate of resolution of ST segment elevations. In the 11 control patients, the sum of ST segment elevations (ΣST) fell after 2 hours to an average of 93.5% ± 17.3% (SEM) and after 24 hours to 89.6% ± 7.6% of the initial values, while the number of electrodes exhibiting ST segment elevations exceeding 0.1 mV (NST) fell to 98.0% ± 12.3% and 94.3% ± 10.4% of the initial values respectively. In the hyaluronidase-treated group, at the same time ΣST fell significantly more (P < 0.05), to 54.1% ± 5.0% and 51.3% ± 11.8% and NST was also more markedly reduced (P < 0.05) to 50.7% ± 7.8% and 50.1% ± 12.4%, thus indicating that hyaluronidase can accelerate the reduction of myocardial ischemic injury in patients with acute myocardial infarction.
MAROKO PR, DAVIDSON DM, LIBBY P, HAGAN AD, BRAUNWALD E. Effects of Hyaluronidase Administration on Myocardial Ischemic Injury in Acute Infarction: A Preliminary Study in 24 Patients. Ann Intern Med. ;82:516–520. doi: 10.7326/0003-4819-82-4-516
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Published: Ann Intern Med. 1975;82(4):516-520.
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