CARL S. ALEXANDER, M.D.
To the editor: In a recent issue Kolts, Herbst, and McGuigan ( 1 ) report on having administered intravenous calcium and secretin to 3 patients with the Zollinger-Ellison syndrome; they confirmed the results of others that administration of these agents resulted in hypergastrinemia. Isenberg and colleagues (2) suggested that the rise in serum calcium might be responsible for the increased level of gastrin. Despite the fact that after secretin infusion the serum calcium appeared to increase 1.0 mg/dl, 1.0 mg/dl, and 0.5 mg/dl in Patients 1, 2, and 3, respectively, Kolts, Herbst, and McGuigan chose to consider the increase as
ALEXANDER CS. Zollinger-Ellison Syndrome: Calcium, Secretin, Gastrin. Ann Intern Med. ;82:591–592. doi: 10.7326/0003-4819-82-4-591
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Published: Ann Intern Med. 1975;82(4):591-592.
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