GENE G. HUNDER, M.D., F.A.C.P.; SHELDON G. SHEPS, M.D., F.A.C.P.; GEORGE L. ALLEN, M.D., F.A.C.P.; JOHN W. JOYCE, M.D., F.A.C.P.
Alternate-day corticosteroid therapy was compared with two daily corticosteroid regimens for the treatment of giant cell arteritis. In a prospective study 60 patients with this disease were randomly assigned to three treatment groups: group A, 15 mg of prednisone every 8 hours; group B, 45 mg of prednisone every morning; and group C, 90 mg of prednisone every other morning. After 1 month of treatment, the arteritis seemed to be completely suppressed in 18 patients in group A and 16 in group B but in only 6 in group C. In the 14 other patients in group C, the continuing symptoms were cyclic and developed during the day steroids were not given. By changing to a daily regimen, the arteritis was controlled in most patients in group C. Adverse reactions to prednisone were noted frequently in groups A and B but rarely in group C.
HUNDER GG, SHEPS SG, ALLEN GL, JOYCE JW. Daily and Alternate-Day Corticosteroid Regimens in Treatment of Giant Cell Arteritis: Comparison in a Prospective Study. Ann Intern Med. ;82:613–618. doi: 10.7326/0003-4819-82-5-613
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Published: Ann Intern Med. 1975;82(5):613-618.
Giant Cell Arteritis/Polymyalgia Rheumatica, Neurology, Rheumatology, Vasculitides.
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