G. THEODOROPOULOS, M.D.; A. ARCHIMANDRITIS, M.D.; B. ANGELOPOULOS, M.D.
In 1970 Sherlock and co-workers (1) were the first to describe five cases of malignant hepatoma associated with a positive Au(1) serologic test. Some months later, there was a report of a high prevalence of Au(1) in the serum of Ugandan patients with hepatocellular carcinoma. These findings "provided suggestive evidence that virus hepatitis B at least is a precancerous condition" (2). However, the results of other investigations carried out in different areas of the world to establish this association are controversial. A high prevalence of Au(1) has been observed in patients suffering from hepatoma in Senegal, Uganda, India, Spain, Chile,
THEODOROPOULOS G, ARCHIMANDRITIS A, ANGELOPOULOS B. Australia Antigen and Malignant Hepatoma. Ann Intern Med. 1975;82:809–810. doi: 10.7326/0003-4819-82-6-809
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Published: Ann Intern Med. 1975;82(6):809-810.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Liver Cancer, Liver Disease.
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