DAVID RUBIN; PHIL PETERSON, M.D.; JAY I. MELTZER, M.D.
To the editor: In the NIH conference on Wegener's granulomatosis (Ann Intern Med 81:513-525, 1974), one of the authors (Dr. Horn) concludes that the renal lesions are the result of "immune complex deposition (that) probably triggers focal and segmental injury to the glomerulus." He supports this view by citing electron microscopic findings of subepithelial deposits and immunofluorescence studies showing IgG and complement.
Concerning the electron microscopic evidence, the author states that subepithelial deposits were found in only 3 of 19 specimens in their own series. This is the largest series in the literature and is not in disagreement with other
RUBIN D, PETERSON P, MELTZER JI. Renal Lesions in Wegener's Granulomatosis. Ann Intern Med. ;82:849–850. doi: 10.7326/0003-4819-82-6-849
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Published: Ann Intern Med. 1975;82(6):849-850.
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