ROBERT A. MINOW, M.D.; JEFFREY A. GOTTLIEB, M.D.; LEON FRAZIN, M.D.; EFRAIN GARCIA, M.D.
To the editor: Rinehart, Lewis, and Balcerzak (1) recommend the use of systolic time intervals for the early detection of adriamycin cardiotoxicity. As they suggest, the early detection of significant cardiotoxicity would allow a more accurate decision on the dose limitation of adriamycin. Their Figure 1A suggests a continuous increase in systolic time intervals with increasing adriamycin dose, yet they only give the data on two patients. It would be more interesting to see if a dose response curve could be formed from all their cases.
In eight of their nine (89%) patients who received > 300 mg/m2 body surface
MINOW RA, GOTTLIEB JA, FRAZIN L, GARCIA E. Adriamycin Cardiotoxicity. Ann Intern Med. ;82:855–857. doi: 10.7326/0003-4819-82-6-855
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Published: Ann Intern Med. 1975;82(6):855-857.
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