RICHARD S. KRONENBERG, M.D., F.A.C.P.; MANUEL G. COSIO, M.D.; JOHN E. STEVENSON, M.D.; CHARLES W. DRAGE, M.D., F.A.C.P.
Although the induction of acute respiratory failure in patients with chronic obstructive lung disease and CO2 retention by morphine or barbituates is well-known, few data are available on the use of oral antianxiety drugs in these patients. Accordingly, we studied the consequences of administering diazepam to six patients with severe but stable obstructive lung disease and hypercapnia.
The patients were electively admitted to the hospital clinical research center for the study, for which they gave informed consent. Before beginning diazepam therapy they were studied with spirometry, blood gases, and measurement of their ventilatory responses to hypoxia and hypercapnia. These pretreatment
KRONENBERG RS, COSIO MG, STEVENSON JE, DRAGE CW. The Use of Oral Diazepam in Patients with Obstructive Lung Disease and Hypercapnia. Ann Intern Med. ;83:83–84. doi: 10.7326/0003-4819-83-1-83
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Published: Ann Intern Med. 1975;83(1):83-84.
Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
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