JAMES D. LAKIN, Ph.D., M.D.; DOUGLAS M. STRONG, Ph.D.; KENNETH W. SELL, M.D., Ph.D.
A patient with aplastic anemia was immunosuppressed with cyclophosphamide and transplanted with allogenic bone marrow. While lacking demonstrable T-cell activity posttransplantation, he developed a generalized macular erythematous eruption and fever, clinically attributed to intranasal polymyxin B. A specific IgE antibody, demonstrated by direct skin testing, Prausnitz-Küstner passive transfer, and indirect passive hemagglutination was temporally related to the reaction. Discontinuation of the drug led to prompt defervescence and resolution of the drug eruption.
LAKIN JD, STRONG DM, SELL KW. Polymyxin B Reactions, IgE Antibody, and T-Cell Deficiency: Immunochemical Studies in a Patient after Bone Marrow Transplantation. Ann Intern Med. ;83:204–207. doi: 10.7326/0003-4819-83-2-204
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Published: Ann Intern Med. 1975;83(2):204-207.
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