MARIO-ANTOINE DICATO, M.D.; LEONARD ELLMAN, M.D.
The development of infarction and necrosis of the skin and subcutaneous tissue is an uncommon complication of anticoagulant therapy with coumarin derivatives. We have recently cared for a patient with bilateral breast necrosis due to sodium warfarin (Coumadin®) whose illness was complicated by disseminated intravascular coagulation and microangiopathic hemolytic anemia. Although intravenous heparin has been reported to be of value in the treatment of coumarin necrosis (1, 2), we are unaware of any previous case in which disseminated intravascular coagulation has been documented. We present here a case in which bilateral breast necrosis occurred after the use of sodium warfarin
DICATO M, ELLMAN L. Coumadin®-lnduced Necrosis of Breast, Disseminated Intravascular Coagulation, and Hemolytic Anemia. Ann Intern Med. ;83:233–234. doi: 10.7326/0003-4819-83-2-233
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Published: Ann Intern Med. 1975;83(2):233-234.
Coagulopathies, Hematology/Oncology, Red Cell Disorders.
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